2. Signaling Pathways
  3. GPCR/G Protein
  4. P2Y Receptor

P2Y Receptor

P2Y Receptor

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P2Y receptors are a class of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides (ATP, UTP, and UDP). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain.

The P2Y family can be further divided into a subfamily of five P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs (“P2Y1-like”) that stimulate phospholipase C (PLC) through Gq protein and a second subfamily of P2Y12, P2Y13, and P2Y14Rs (“P2Y12-like”) that inhibit adenylate cyclase through Gi protein. Other effector pathways have been documented, such as coupling of the P2Y11R to Gs as well as to Gq in some cells to induce stimulation of cyclic AMP production.

P2Y Receptor Isoform Specific Products:

P2Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-150524
    UDP-Galactose
    		Agonist
    UDP-Galactose is a monosaccharide involved in nucleotide sugar metabolism. UDP-Galactose and its derivatives act as a natural agonist for Gi protein-conjugated P2Y14 receptors in the immune system (IC50=0.67 μM, hP2Y14).
    UDP-Galactose
  • HY-15284R
    Prasugrel (Standard)
    		Inhibitor
    Prasugrel (Standard) is the analytical standard of Prasugrel. This product is intended for research and analytical applications. Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel (Standard)
  • HY-15284S3
    Prasugrel-13C6
    		Inhibitor
    Prasugrel-13C6 is a deuterated labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel-<sup>13</sup>C<sub>6</sub>
  • HY-RS09919
    P2RY12 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY12 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY12 Human Pre-designed siRNA Set A
    P2RY12 Human Pre-designed siRNA Set A
  • HY-RS09930
    P2ry2 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry2 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry2 Rat Pre-designed siRNA Set A
    P2ry2 Rat Pre-designed siRNA Set A
  • HY-RS09932
    P2ry4 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry4 Mouse Pre-designed siRNA Set A
    P2ry4 Mouse Pre-designed siRNA Set A
  • HY-167855
    MRS4833
    		Antagonist
    MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model.
    MRS4833
  • HY-113359AS1
    Uridine 5'-diphosphate-13C9 dilithium
    		Agonist
    Uridine 5'-diphosphate-13C9 dilithium is 13C-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.
    Uridine 5'-diphosphate-<sup>13</sup>C<sub>9</sub> dilithium
  • HY-113359
    Uridine 5'-diphosphate
    		Agonist
    Uridine 5'-diphosphate is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.
    Uridine 5'-diphosphate
  • HY-103064
    2-Methylthio-AMP sodium
    		Antagonist
    2-Methylthio-AMP sodium is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP sodium is an inhibitor of ADP-dependent platelet aggregation.
    2-Methylthio-AMP sodium
  • HY-108648A
    2-MeSADP
    		Agonist
    2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-MeSADP has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-MeSADP induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1.
    2-MeSADP
  • HY-RS09923
    P2ry13 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry13 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry13 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry13 Mouse Pre-designed siRNA Set A
    P2ry13 Mouse Pre-designed siRNA Set A
  • HY-RS09920
    P2ry12 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry12 Mouse Pre-designed siRNA Set A
    P2ry12 Mouse Pre-designed siRNA Set A
  • HY-108650
    2-Thio-UTP tetrasodium
    		Agonist
    2-Thio-UTP tetrasodium is a potent P2Y2, P2Y4 and P2Y6 agonist, which an be used for the research of cancer.
    2-Thio-UTP tetrasodium
  • HY-RS09914
    P2RY1 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY1 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY1 Human Pre-designed siRNA Set A
    P2RY1 Human Pre-designed siRNA Set A
  • HY-RS09927
    P2ry14 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry14 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry14 Rat Pre-designed siRNA Set A
    P2ry14 Rat Pre-designed siRNA Set A
  • HY-RS09921
    P2ry12 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry12 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry12 Rat Pre-designed siRNA Set A
    P2ry12 Rat Pre-designed siRNA Set A
  • HY-170950
    P2Y14 antagonist 1
    		Inhibitor
    P2Y14 antagonist 1 (compound 45) is a high selective and orally active P2Y14R antagonist with an IC50 of 0.70 nM. P2Y14R antagonist 1 demonstrates significant anti-inflammatory efficacy, effectively mitigating the pulmonary infiltration of immune cells and inflammatory response through suppressing the NLRP3 signaling pathway. P2Y14R antagonist 1 has the potential for the research of acute lung injury.
    P2Y14 antagonist 1
  • HY-RS09926
    P2ry14 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry14 Mouse Pre-designed siRNA Set A
    P2ry14 Mouse Pre-designed siRNA Set A
  • HY-RS09922
    P2RY13 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY13 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY13 Human Pre-designed siRNA Set A
    P2RY13 Human Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
P2Y Receptor Isoform Comparison

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